Abstract

The diagnosis of nanodiagnosis it is the use of nanodevices in an early detection at the cellular and molecular levels of diseases or their predestination. With In-vitro diagnostics, in order to evaluate the early existence of a disease, classify and quantify toxic molecules, tumeor cells or infectious diseases, nanotechnologies may improve the efficiency and sensitivity of diagnostic approaches by means of fluids such as saliva or tissue samples in which selective nanoscales perform multiple analyses on the subcellular scale. In the dental interest, the high mortality rate of oral squamous cell carcinoma is often attributed to difficulties in detecting the disease at an early treatable stage. In recent years, the ability of gold nanoparticles subjected to surface plasmon resonance capable of causing an optical contrast to discriminate between cancer and normal cells, and their conjugation with antibodies, has been explored, allowing the expression of relevant biomarkers to be traced for molecular imaging in the reflectance confocal microscope, demonstrating its potential for cancer detection in reflection based imaging systems on the basis of biomolecular changes.

Local anaesthesia: Local anaesthesia is one of the most common dental procedures. In recent years the development of bio-compatible microsphere and nanospheric drug regulated devices has turned them into ideal tools to use such anaesthetic substances to increase their protection, thereby reducing their physiologically harmful effects and reducing their effects by lacking vasoconstricting substances.